Conditional overexpression of PPARα in intestinal epithelium diminishes GIP enteroendocrine cells and circulating hormone levels
Jacob J. Socha, Swathi Pavithran, Courtney A. Burger, Rebekah Karns, Avelina W. Lee, Richard Lang, Maria E. Moreno-Fernandez, Stephen W. Standage, Kelli L. VanDussen · 2026
Read Conditional overexpression of PPARα in intestinal epithelium diminishes GIP enteroendocrine cells and circulating hormone levels by Jacob J. Socha, Swathi Pavithran, Courtney A. Burger, Rebekah Karns, Avelina W. Lee, Richard Lang, Maria E. Moreno-Fernandez, Stephen W. Standage, Kelli L. VanDussen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13542957.txt.
Description
Agonists of the lipid-sensing PPAR nuclear receptors, including PPARα, are being explored as therapies for metabolic disorders due to their roles in metabolic and anti-inflammatory processes. PPARα transcriptional programs have tissue-dependent features, yet there is a lack of genetic tools to study tissue-specific signaling activation without the addition of a systemic agonist.
Catalog record
| CREATOR | Jacob J. Socha, Swathi Pavithran, Courtney A. Burger, Rebekah Karns, Avelina W. Lee, Richard Lang, Maria E. Moreno-Fernandez, Stephen W. Standage, Kelli L. VanDussen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |