Is There a Difference in Occurrence of Complications Between Adults With Hemoglobin SS and Hemoglobin SC Disease: An Extended Systematic Review
Martijn van der Meer, Kim Velsink, Wing H. Tong, Jan W. Schoones · 2026
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Description
Martijn van der Meer and colleagues published a 2026 systematic review comparing complications in adults with the two most common sickle cell genotypes, haemoglobin SS and haemoglobin SC. Sickle cell disease damages organs through repeated blockages of small blood vessels, yet the pattern of harm differs by genotype. Following standard review guidelines, the team screened the literature and kept 31 studies that directly informed the comparison.
Painful vaso-occlusive crises were the most common acute problem in both groups, striking SS patients more often. SC patients generally had a milder course for acute events, but chronic complications, especially in the eyes and lungs, were more common in that group. Neither genotype escapes progressive organ damage, the authors conclude, because recurring ischaemic injury and inflammation accumulate in both. They use the contrast to point out where genotype-specific monitoring and future research should focus.
Catalog record
| CREATOR | Martijn van der Meer, Kim Velsink, Wing H. Tong, Jan W. Schoones |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43001 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |