Lonicera japonica‐Derived Nanovesicles Ameliorate Acute Lung Injury by Suppressing Neutrophil Extracellular Traps Formation in Mice
Xi Lin, Jian Lin, Yezi Zhang, Xinyan Zhang, Xinghua Liu, Hongying Cao, Huan Shen, Jianming Liang, Zhenhua Dai, Siyuan Xu, Xingdong Lin · 2026
Read Lonicera japonica‐Derived Nanovesicles Ameliorate Acute Lung Injury by Suppressing Neutrophil Extracellular Traps Formation in Mice by Xi Lin, Jian Lin, Yezi Zhang, Xinyan Zhang, Xinghua Liu, Hongying Cao, Huan Shen, Jianming Liang, Zhenhua Dai, Siyuan Xu, Xingdong Lin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13542943.txt.
Description
Xi Lin and colleagues published a 2026 animal study testing nanovesicles from honeysuckle, Lonicera japonica, as a treatment for acute lung injury. These tiny plant-derived sacs were isolated and given to mice whose lungs had been injured with a bacterial toxin. Much of the damage in this condition comes from neutrophil extracellular traps, webs of DNA that white blood cells throw out and that can harm lung tissue when produced excessively.
The vesicles gathered in lung neutrophils, and treated mice kept their weight and activity better while lung injury eased. Inflammatory signals fell, fewer neutrophils crowded the lungs, and fewer traps formed. Markers suggested the vesicles calmed a self-digestion process in cells that feeds trap formation. When a drug that forces trap release was added, the benefit vanished, supporting the proposed mechanism. Plant nanovesicles aimed at the lung could become a new treatment direction, though human testing lies ahead.
Catalog record
| CREATOR | Xi Lin, Jian Lin, Yezi Zhang, Xinyan Zhang, Xinghua Liu, Hongying Cao, Huan Shen, Jianming Liang, Zhenhua Dai, Siyuan Xu, Xingdong Lin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |