Extranodal Marginal Zone Lymphoma: Integrating Etiology, Microenvironment, and Genetics Into Clinical Decision‐Making
Mamdouh Skafi, Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Marco Fiorillo, Eugenio Lucia, Graziella D'Arrigo, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Giovanni Tripepi, Fortunato Morabito, Massimo Gentile · 2026
Read Extranodal Marginal Zone Lymphoma: Integrating Etiology, Microenvironment, and Genetics Into Clinical Decision‐Making by Mamdouh Skafi, Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Marco Fiorillo, Eugenio Lucia, Graziella D'Arrigo, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Giovanni Tripepi, Fortunato Morabito, Massimo Gentile (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13542940.txt.
Description
Mamdouh Skafi and colleagues published a 2026 review of extranodal marginal zone lymphoma, a slow-growing B-cell cancer that arises in tissues outside the lymph nodes. Unusually for a cancer, its growth is often fuelled by long-standing infection or autoimmune irritation at a particular body site, which builds abnormal lymphoid tissue there. Over time, genetic changes, many converging on a signalling pathway called NF-kappaB, let the lymphoma escape its dependence on that trigger.
Because origin shapes behaviour, treatment is matched to site, stage, and biology, favouring the gentlest approach that can control the disease. Antibiotics aimed at a driving infection, or focused radiotherapy, can cure some localised cases. Antibody-based chemotherapy and newer targeted drugs are held back for spread or resistant disease. The review argues this lymphoma shows how biologically informed, restrained treatment can serve patients with slow-growing cancers generally.
Catalog record
| CREATOR | Mamdouh Skafi, Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Marco Fiorillo, Eugenio Lucia, Graziella D'Arrigo, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Giovanni Tripepi, Fortunato Morabito, Massimo Gentile |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57425 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |