Maternal tributyltin exposure is associated with male-biased immune dysregulation across generations
Richard C. Chang, Michelle Avila, Yikai Huang, Kaitlin To, Juan Antonio Aguilar-Pimentel, Thure Adler, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Bruce Blumberg · 2026
Read Maternal tributyltin exposure is associated with male-biased immune dysregulation across generations by Richard C. Chang, Michelle Avila, Yikai Huang, Kaitlin To, Juan Antonio Aguilar-Pimentel, Thure Adler, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Bruce Blumberg (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13542722.txt.
Description
Richard Chang and co-authors test whether a mother's exposure to a tin chemical warps immune balance in her offspring, and in theirs. Their 2026 study deals with tributyltin, a chemical that disrupts hormones and fattens mice across generations. Blood immune profiles came from a large mouse clinic data set for first-generation offspring. A fresh line of mice gave spleen markers and swelling signals in blood for first and third generations.
Exposed first offspring showed more B cells, fewer T cells, and fewer killer cells. In males, spleen markers for T cells fell while swelling signals rose. Unexposed third-generation males showed the same bent pattern, while females did not.
Catalog record
| CREATOR | Richard C. Chang, Michelle Avila, Yikai Huang, Kaitlin To, Juan Antonio Aguilar-Pimentel, Thure Adler, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Bruce Blumberg |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |