Induced degradation of Ufd1 reveals regulation of cohesin by the VCP/p97Ufd1-Npl4 complex
Daniella Munro, Maike Reinders, Aikaterini Pravi, Johannes van den Boom, Pinki Gahlot, Ekaterina Isaakova, Caio AB Oliveira, Dominik Boos, Petra Beli, Hemmo Meyer · 2026
Read Induced degradation of Ufd1 reveals regulation of cohesin by the VCP/p97Ufd1-Npl4 complex by Daniella Munro, Maike Reinders, Aikaterini Pravi, Johannes van den Boom, Pinki Gahlot, Ekaterina Isaakova, Caio AB Oliveira, Dominik Boos, Petra Beli, Hemmo Meyer (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13542637.txt.
Description
Daniella Munro and co-authors study how a protein machine removes a ring that holds sister DNA strands together, in a 2026 paper. The machine, VCP/p97 with its Ufd1-Npl4 adapter, handles tagged proteins on chromatin. Its many jobs and partners have made its exact roles hard to untangle.
The team rapidly destroyed the Ufd1 part in human cells and profiled the tagged proteins that changed. They found several chromatin regulators as targets, including a subunit of the cohesin ring. During the DNA copying phase, the machine removes a subset of those rings so copying can proceed freely. Blocking that removal stalled copying and caused DNA damage. The findings link this cleanup step to genome stability.
Catalog record
| CREATOR | Daniella Munro, Maike Reinders, Aikaterini Pravi, Johannes van den Boom, Pinki Gahlot, Ekaterina Isaakova, Caio AB Oliveira, Dominik Boos, Petra Beli, Hemmo Meyer |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |