Assessing genetic risk factors for early-onset coronary artery disease in Iranians
Ilaria Mancini, Maria Teresa Pagliari, Saeed Sadeghian, Seyed Hesameddin Abbasi, Hamidreza Poorhosseini, Mohammad Ali Boroumand, Masoumeh Lotfi-Tokaldany, Emanuela Pappalardo, Pasquale Agosti, Frits R Rosendaal, Flora Peyvandi · 2026
Read Assessing genetic risk factors for early-onset coronary artery disease in Iranians by Ilaria Mancini, Maria Teresa Pagliari, Saeed Sadeghian, Seyed Hesameddin Abbasi, Hamidreza Poorhosseini, Mohammad Ali Boroumand, Masoumeh Lotfi-Tokaldany, Emanuela Pappalardo, Pasquale Agosti, Frits R Rosendaal, Flora Peyvandi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13542590.txt.
Description
Ilaria Mancini and colleagues published a 2026 genetic study of early-onset coronary artery disease in Iranians, a population largely missing from research dominated by European and East Asian samples. The case-control study enrolled 697 patients whose artery disease was confirmed by angiography at young ages, alongside 911 matched controls. Twenty-four gene variants were tested: twelve already linked to coronary disease elsewhere, and twelve candidates from genes governing blood clotting.
Only some known variants replicated in this population, and several effects appeared only within particular ethnic groups, underlining how ancestry shapes genetic risk. A six-variant risk score separated people clearly, with each extra risk allele raising odds by about a fifth. Genetic burden also multiplied the danger from metabolic conditions far beyond simple addition. The authors argue that risk tools built on other populations cannot simply be imported into Iranian care.
Catalog record
| CREATOR | Ilaria Mancini, Maria Teresa Pagliari, Saeed Sadeghian, Seyed Hesameddin Abbasi, Hamidreza Poorhosseini, Mohammad Ali Boroumand, Masoumeh Lotfi-Tokaldany, Emanuela Pappalardo, Pasquale Agosti, Frits R Rosendaal, Flora Peyvandi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |