Temporal impact of metritis and systemic antibiotics on immune cell function inferred from the blood leukocyte transcriptome
Monica O. Caldeira, Joao G.N. Moraes, Scott E. Poock, Matthew C. Lucy · 2026
Read Temporal impact of metritis and systemic antibiotics on immune cell function inferred from the blood leukocyte transcriptome by Monica O. Caldeira, Joao G.N. Moraes, Scott E. Poock, Matthew C. Lucy (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13542448.txt.
Description
Monica Caldeira and colleagues published a 2026 study tracking how the immune system of dairy cows recovers from metritis. That uterine infection strikes many cows soon after calving, and the study also asks how antibiotics change recovery. Blood from 23 first-lactation Holstein cows — some healthy, others with metritis, treated or not — was sequenced at one and three weeks after diagnosis. Gene activity in white blood cells served as a fingerprint of which immune cells dominated at each moment.
Healthy cows showed a B lymphocyte pattern, while sick cows showed inflammatory myeloid cells and cytotoxic lymphocytes. Untreated sick cows drifted back toward the healthy pattern within three weeks. Antibiotic-treated cows instead followed a different path, with an early wave of killer cells and a later wave of inflammatory cells. Antibiotics therefore redirect recovery's sequence rather than simply speeding up the natural one, with implications for treatment choices.
Catalog record
| CREATOR | Monica O. Caldeira, Joao G.N. Moraes, Scott E. Poock, Matthew C. Lucy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31955 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |