Chitosan nanoparticles for mucosal and needle-free vaccination
Changchun Chen, Cheng Zhang, Shanyuan Zhu, Shinuo Cao · 2026
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Description
Changchun Chen and colleagues surveyed shell-derived tiny carriers for needle-free vaccines. Published in 2026, the review covers chitosan bits, made from shell waste, that steady vaccine cargo, boost nose-and-mouth dosing, and spark immune fire. Standard shots struggle with fragile cargo, strict cold chains, and weak mucosal defense.
Tuning shell-sugar makeup lets makers set charge, stickiness, and toughness, shaping carriers for killed, subunit, and gene-based vaccines. Tests span flu, COVID-19, TB, and even cancer shots, with heat-stable designs easing cold-chain strain. Yet no shell-particle vaccine has won clinic approval, and scale-up, batch sameness, and rule-setting still block the road. Readers get design rules for tough, working mucosal shots.
Catalog record
| CREATOR | Changchun Chen, Cheng Zhang, Shanyuan Zhu, Shinuo Cao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 90 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |