Insights into ctDNA assessment to detect minimal residual disease (MRD) in localized colorectal cancer
Ibone Labiano, David Guerrero-Setas, Ana Elsa Huerta, Elena Mata, Gorka Alkorta-Aranburu, Gonzalo R Ordoñez, Pedro Berraondo, Arturo Lecumberri, Patricia Ochoa, Irene Caseda, Rosalinda Termini, Borja Agirre-Mikelarena, Irene Amat, Natalia Castro, Hugo Arasanz, Maria Alsina, Ruth Vera · 2026
Read Insights into ctDNA assessment to detect minimal residual disease (MRD) in localized colorectal cancer by Ibone Labiano, David Guerrero-Setas, Ana Elsa Huerta, Elena Mata, Gorka Alkorta-Aranburu, Gonzalo R Ordoñez, Pedro Berraondo, Arturo Lecumberri, Patricia Ochoa, Irene Caseda, Rosalinda Termini, Borja Agirre-Mikelarena, Irene Amat, Natalia Castro, Hugo Arasanz, Maria Alsina, Ruth Vera (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13542205.txt.
Description
Ibone Labiano and colleagues report a pilot study in 2026. Blood tests hunted leftover cancer DNA after surgery. The cancer was localised colorectal cancer. The goal was catching minimal residual disease early. Scans cannot see such tiny traces. Forty-seven patients joined, all with high-risk tumors.
Tumor tissue was sequenced first for each patient. Plasma was drawn four weeks after surgery. Judged by blood alone, the test caught few relapses. It cleared most patients who stayed well. Adding tissue results lifted detection a lot. Accuracy rose markedly as well. Agreement between tissue and plasma stayed low. Lung relapses escaped detection entirely.
Catalog record
| CREATOR | Ibone Labiano, David Guerrero-Setas, Ana Elsa Huerta, Elena Mata, Gorka Alkorta-Aranburu, Gonzalo R Ordoñez, Pedro Berraondo, Arturo Lecumberri, Patricia Ochoa, Irene Caseda, Rosalinda Termini, Borja Agirre-Mikelarena, Irene Amat, Natalia Castro, Hugo Arasanz, Maria Alsina, Ruth Vera |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41525 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |