Targeting mitophagy for neuroprotection: mechanisms and therapeutic opportunities
Jiahui Yang, Jianfeng Li, Xintong Hou, Yifei Zheng, Zeyu Zhao, Ting Zhou, Tongwei Jing, Jiming Kong, Guohui Zhang, Ying Guo · 2026
Read Targeting mitophagy for neuroprotection: mechanisms and therapeutic opportunities by Jiahui Yang, Jianfeng Li, Xintong Hou, Yifei Zheng, Zeyu Zhao, Ting Zhou, Tongwei Jing, Jiming Kong, Guohui Zhang, Ying Guo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13542155.txt.
Description
Jiahui Yang and colleagues surveyed mitophagy, the cell's cleanup of damaged energy hubs, as a shield for neurons. Published in 2026, the review explains how neurons, with huge energy needs and weak regrowth, suffer when energy hubs fail. Failure drains energy, spills harmful oxygen, and upsets calcium, driving stress and cell death.
Mitophagy clears broken mitochondria through the cell's reuse route, guarding energy output and network health. Control routes include PINK1-Parkin and docking paths with BNIP3 and FUNDC1. Weak mitophagy marks Alzheimer's, Parkinson's, ALS, and Huntington's disease, adding to damage and nerve stress. Drug, gene, and diet plans that boost mitophagy show early hope but face a hard clinic leap. Readers get a map of a strong target for saving neurons.
Catalog record
| CREATOR | Jiahui Yang, Jianfeng Li, Xintong Hou, Yifei Zheng, Zeyu Zhao, Ting Zhou, Tongwei Jing, Jiming Kong, Guohui Zhang, Ying Guo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |