Evolving landscape of targeted immunotherapeutic interventions and CAR-T therapy for acute myeloid leukemia
Tara Chand Yadav, Shanid Mohiyuddin, Gerhard C. Hildebrandt, Senthilnathan Palaniyandi · 2026
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Description
Tara Chand Yadav and colleagues mapped the shifting immune-attack toolkit for acute myeloid leukemia. Published in 2026, the review surveys new-wave immune treatments aimed at leukemia blast cells. AML is fast, varied, and marked by rogue blast growth plus niche remaking, and older treatments falter against shifting stubborn forms.
The review walks through CAR-T cells, checkpoint blockers, drug-linked antibodies, and antibody-based drugs, weighing how each hunts blast cells. It also weighs hurdles like drug fight-back, relapse, and graft-versus-host risk that shadow donor-cell attacks. Breakthroughs and open gaps get equal airing, with an eye to safer, sharper patient-matched use. Readers get a current field guide to immune options beyond chemo and transplant.
Catalog record
| CREATOR | Tara Chand Yadav, Shanid Mohiyuddin, Gerhard C. Hildebrandt, Senthilnathan Palaniyandi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |