Cancer-associated adipomes promote invadopodia formation and enhance metastatic potential in triple-negative breast cancer
Hariprasad Thangavel, Dhanya Dhanyalayam, Kezia Lizardo, Shivani Bansal, Junfeng Ma, Robert Glazer, Jyothi Nagajyothi · 2026
Read Cancer-associated adipomes promote invadopodia formation and enhance metastatic potential in triple-negative breast cancer by Hariprasad Thangavel, Dhanya Dhanyalayam, Kezia Lizardo, Shivani Bansal, Junfeng Ma, Robert Glazer, Jyothi Nagajyothi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13542080.txt.
Description
Hariprasad Thangavel and colleagues showed fat-cell parcels can drive spread in triple-negative breast cancer. Published in 2026, the study pulled large adipomes, tiny fat-cell parcels, from patient blood and mouse tumor fat. Triple-negative disease lacks hormone and HER2 targets, leaving chemo as the main option, and it returns early with distant spread.
Blood parcels from spread-stage patients pushed healthy breast cells toward a mobile, stem-like state and spurred foot-like prongs. Mouse tumor-fat parcels, rich in phospholipids, rewired mouse cancer cells in gene and protein work. Both routes switched on stress MAPK signals and builders for cell frames, energy, and protein making, all feeding prongs and matrix breakdown. The authors name fat parcels as potent spread drivers and a fresh drug target.
Catalog record
| CREATOR | Hariprasad Thangavel, Dhanya Dhanyalayam, Kezia Lizardo, Shivani Bansal, Junfeng Ma, Robert Glazer, Jyothi Nagajyothi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |