Mendelian Randomization Unveils Poly(ADP-ribose) Polymerase 1 as Causal Plasma Protein Target in Melanoma, Integrated Multi-omics
Feng Lu, Wenkang Luan, Hanyi Jiang, Shaojun Ma, Hongru Ruan · 2026
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Description
Five researchers in China used a genetics-based method to test whether a DNA repair protein helps cause melanoma, in a study published in 2026. Many blood proteins correlate with this skin cancer, but correlation cannot prove cause. The team applied Mendelian randomization, which uses gene variants as natural experiments, to proteomic data from two large sources. Follow-up checks weighed whether the flagged protein could serve as a drug target.
The protein, called PARP1, came out as a causal risk factor for melanoma. Tumors with more of it were tied to worse survival for patients. Lab and single-cell work showed the protein plays varied roles across cell types while pushing tumor growth overall. Blocking PARP is already a known strategy in other cancers. The authors present PARP1 as a driver of melanoma and a candidate for targeted treatment trials.
Catalog record
| CREATOR | Feng Lu, Wenkang Luan, Hanyi Jiang, Shaojun Ma, Hongru Ruan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |