Effect of six weeks ubiquinol supplementation on mitochondrial respiratory function and exercise capacity in healthy males
Jarred P. Acton, Nehal S. Alsharif, Jack W. Bond, Stuart P. Cocksedge, Abbie G. Mclellan, Donald L. Peden, Mark P. Funnell, Hannah F. Dugdale, Lewis J. James, Richard A. Ferguson, Tom Clifford, Stephen J. Bailey · 2026
Read Effect of six weeks ubiquinol supplementation on mitochondrial respiratory function and exercise capacity in healthy males by Jarred P. Acton, Nehal S. Alsharif, Jack W. Bond, Stuart P. Cocksedge, Abbie G. Mclellan, Donald L. Peden, Mark P. Funnell, Hannah F. Dugdale, Lewis J. James, Richard A. Ferguson, Tom Clifford, Stephen J. Bailey (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13541835.txt.
Description
Acton and colleagues run a careful supplement trial on ubiquinol, the absorbable form of coenzyme Q10, a molecule that ferries electrons inside mitochondria, the cell's power stations. The oxidised supplement form has repeatedly disappointed in exercise studies. Their 2026 double-blind trial randomised 54 healthy, recreationally active men to take a daily ubiquinol dose or placebo for six weeks. It biopsied muscle to measure mitochondrial breathing and leak proteins, and tested severe-intensity cycling endurance before and after.
Blood coenzyme levels rose as intended, and one mitochondrial measure improved. A control ratio suggesting tighter coupling between oxygen burning and energy capture fell significantly in the supplemented group against both its own baseline and placebo. The suspected leak proteins did not change, leaving the mechanism open, and the end of the abstract's report gives no performance verdict, so the endurance benefit remains unproven by the headline data.
Catalog record
| CREATOR | Jarred P. Acton, Nehal S. Alsharif, Jack W. Bond, Stuart P. Cocksedge, Abbie G. Mclellan, Donald L. Peden, Mark P. Funnell, Hannah F. Dugdale, Lewis J. James, Richard A. Ferguson, Tom Clifford, Stephen J. Bailey |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |