Sjögren’s disease patients with no hyposalivation and with short oral dryness complaints contain more T cells in salivary gland parenchyma
Ting Yang, Silvia C Liefers, Bert van der Vegt, Kornelis S M van der Geest, Karina de Leeuw, Hendrika Bootsma, Frans G M Kroese, Sarah Pringle · 2026
Read Sjögren’s disease patients with no hyposalivation and with short oral dryness complaints contain more T cells in salivary gland parenchyma by Ting Yang, Silvia C Liefers, Bert van der Vegt, Kornelis S M van der Geest, Karina de Leeuw, Hendrika Bootsma, Frans G M Kroese, Sarah Pringle (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13541375.txt.
Description
Ting Yang and seven colleagues count immune cells inside salivary glands of Sjögren's disease patients and relate them to dryness, in a 2026 paper. Nearly all patients lose saliva flow, yet gland infiltration explains flow poorly. Resident killer T cells had recently been tied to gland damage, prompting a closer look.
The team stained parotid gland tissue from antibody-positive patients and non-Sjögren dry-mouth controls. Helper and killer T cell shares were clearly higher in patients' glands. Natural killer cells and macrophages did not differ. Intriguingly, patients with normal saliva flow and the shortest dryness complaints trended toward the most T cells, as if infiltration peaks early. Marker analysis suggested the T cells mix tissue residents with newcomers. The authors propose an early, T-cell-rich phase before glands fail. Catching that phase, they imply, could open a treatment window.
Catalog record
| CREATOR | Ting Yang, Silvia C Liefers, Bert van der Vegt, Kornelis S M van der Geest, Karina de Leeuw, Hendrika Bootsma, Frans G M Kroese, Sarah Pringle |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |