Recognition of pathogenic bacteria by intestinal stem cells promotes adult Drosophila midgut regeneration
Bhavin Uttekar, Marie Srotyr, Sanket Sudam Ravale, Liliana Ewertowska, Rebecca Wafer, Martina Legido, Parthive H. Patel, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia · 2026
Read Recognition of pathogenic bacteria by intestinal stem cells promotes adult Drosophila midgut regeneration by Bhavin Uttekar, Marie Srotyr, Sanket Sudam Ravale, Liliana Ewertowska, Rebecca Wafer, Martina Legido, Parthive H. Patel, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13541249.txt.
Description
Uttekar and colleagues show in twenty twenty-six that gut stem cells in fruit flies can sense harmful bacteria directly and trigger repair. When germs breach the gut lining, nearby cells raise an alarm that rebuilds the tissue. What was not known is whether the stem cells that do the rebuilding can detect invaders themselves, or only react to damage signals.
The team found sensors on the stem cells that spot a bacterial wall part. Spotting it switches on a signal chain that makes stem cells divide. That signal also spreads through the gut lining, shaping the wider repair setting. The authors say direct sensing runs in parallel with damage signals. It may help refill the lining with clean, uninfected cells.
Catalog record
| CREATOR | Bhavin Uttekar, Marie Srotyr, Sanket Sudam Ravale, Liliana Ewertowska, Rebecca Wafer, Martina Legido, Parthive H. Patel, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 113 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |