Pregabalin enhances the proliferative potential of pancreatic cancer in vitro but not in mice with pancreatic cancer
Tomoaki Itaya, Makoto Sano, Ichie Kajiwara, Yukino Oshima, Tomoya Kuramochi, Jinsuk Kim, Osamu Kitajima, Hideaki Ijichi, Takahiro Suzuki · 2026
Read Pregabalin enhances the proliferative potential of pancreatic cancer in vitro but not in mice with pancreatic cancer by Tomoaki Itaya, Makoto Sano, Ichie Kajiwara, Yukino Oshima, Tomoya Kuramochi, Jinsuk Kim, Osamu Kitajima, Hideaki Ijichi, Takahiro Suzuki (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13540837.txt.
Description
Tomoaki Itaya and eight colleagues ask, in a 2026 study, whether pregabalin, a nerve-pain drug often given to cancer patients, can also feed pancreatic cancer growth. A sister drug had raised that worry in earlier work by the same group.
In dishes, two doses of pregabalin increased the number of mouse pancreatic cancer cells. Genetically engineered mice prone to this cancer received the drug daily by mouth, and their pain scores improved. Survival and tumor size, however, did not differ from untreated mice. Immune cell mixes inside tumors shifted toward attacker types, and several inflammatory signals fell. The authors judge the dish effect real yet not confirmed in living animals.
Catalog record
| CREATOR | Tomoaki Itaya, Makoto Sano, Ichie Kajiwara, Yukino Oshima, Tomoya Kuramochi, Jinsuk Kim, Osamu Kitajima, Hideaki Ijichi, Takahiro Suzuki |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39855 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |