Exosomal miRNA-714 derived from adipose tissue macrophages regulates adipocyte glucose and lipid metabolism via IGF1R targeting
Rui Ma, Lei Li, Jing Yang, Sheng Jiang · 2026
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Description
Rui Ma and colleagues trace a tiny RNA message in a 2026 study. Immune cells in fat tissue send this message to fat cells. The message disturbs how fat cells handle sugar and fat. It is called miR-714. It travels in small parcels named exosomes.
The message targets the receptor for a growth factor, IGF1. Database mining first flagged this pairing. Fat mice on a rich diet then confirmed it. Their parcels held more miR-714, and fat held less receptor. Tests in cultured fat cells verified the direct binding. Adding the message cut glucose use, while fat stores climbed. The team proposes this axis as a drug target.
Catalog record
| CREATOR | Rui Ma, Lei Li, Jing Yang, Sheng Jiang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58360 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |