Single-cell and single-nucleus transcriptomics of the dorsal root ganglion in neuropathic pain: cell-state remodeling and translational prospects
Xu-Ran Liao, Huan Zheng, Jiang-Yuan Luo, Bi-Xin Zheng · 2026
Read Single-cell and single-nucleus transcriptomics of the dorsal root ganglion in neuropathic pain: cell-state remodeling and translational prospects by Xu-Ran Liao, Huan Zheng, Jiang-Yuan Luo, Bi-Xin Zheng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13540208.txt.
Description
Xu-Ran Liao, Huan Zheng, Jiang-Yuan Luo, and Bi-Xin Zheng review single-cell studies of nerve pain in two thousand twenty-six. Neuropathic pain resists current drugs, partly because the dorsal root ganglion mixes neurons, glia, immune, and support cells. New sequencing methods can now read gene activity cell by cell.
The review covers nerve injury, diabetic neuropathy, and chemotherapy-induced neuropathy. All three reshape neuron states and glial support, yet they do not share one common program. Injury brings repair states and immune crosstalk, diabetes alters sensory coding and lipid support, and chemotherapy effects vary by drug and sex. Human ganglion atlases help check which findings hold in people. Most studies sample one time point, so causes stay uncertain.
Catalog record
| CREATOR | Xu-Ran Liao, Huan Zheng, Jiang-Yuan Luo, Bi-Xin Zheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |