Cell line–dependent effects of β‑estradiol and testosterone on aurora kinases, GATA3, and associated miRNAs in hepatocellular carcinoma models HepG2 and Huh‑7
Taraneh Rezaei, Mobina Abidi, Yaser Mohammadi, Farnoosh Farzam, Elham Bahreini · 2026
Read Cell line–dependent effects of β‑estradiol and testosterone on aurora kinases, GATA3, and associated miRNAs in hepatocellular carcinoma models HepG2 and Huh‑7 by Taraneh Rezaei, Mobina Abidi, Yaser Mohammadi, Farnoosh Farzam, Elham Bahreini (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13540203.txt.
Description
Taraneh Rezaei and four colleagues explore, in a 2026 cell study, how male and female sex hormones affect liver cancer growth, since this cancer strikes men far more often. Two human liver cancer cell lines with different levels of aggression were exposed to estradiol and testosterone.
In the calmer HepG2 line, both hormones lowered division-driving Aurora kinases, raised GATA3, and paused the cell cycle. The aggressive Huh-7 line moved the opposite way, speeding through early division stages. Small regulatory RNAs shifted in matching patterns in both lines. The authors conclude that the cell's character, not the hormone, decides whether the signal restrains or encourages growth.
Catalog record
| CREATOR | Taraneh Rezaei, Mobina Abidi, Yaser Mohammadi, Farnoosh Farzam, Elham Bahreini |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70681 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |