Protease-serpin-microbiome interactions in inflammatory bowel disease: toward integrated biomarkers of gut health
Meshal Almalki, Camilla R. De Pierri, Tristan Méric, Héla Mkaouar, Donia Slimani, Vincent Mariaule, Sirine Tebassi, Nizar Akermi, Emmanuelle Maguin, Juan Hernandez, Roberto T. Raittz, Moez Rhimi, Francesco Asnicar · 2026
Read Protease-serpin-microbiome interactions in inflammatory bowel disease: toward integrated biomarkers of gut health by Meshal Almalki, Camilla R. De Pierri, Tristan Méric, Héla Mkaouar, Donia Slimani, Vincent Mariaule, Sirine Tebassi, Nizar Akermi, Emmanuelle Maguin, Juan Hernandez, Roberto T. Raittz, Moez Rhimi, Francesco Asnicar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13540094.txt.
Description
Meshal Almalki and eleven co-authors map five decades of research on the interplay between enzymes that cut proteins, their natural blockers, and gut microbes in inflammatory bowel disease. Their paper came out in 2026. An imbalance in this cutting activity can break down the gut barrier and fuel chronic inflammation.
Surveying more than thirteen thousand publications, they find the literature fragmented. Studies of host enzymes, microbial enzymes, and the blockers rarely connect with each other, and coverage is uneven. They gather the evidence tying this three-way axis to barrier strength, local immunity, tissue remodeling, and the gut ecosystem. Treating the axis as one system, they argue, could reveal why the disease varies so much between patients. It could also point to combined markers for diagnosis and to new treatment targets.
Catalog record
| CREATOR | Meshal Almalki, Camilla R. De Pierri, Tristan Méric, Héla Mkaouar, Donia Slimani, Vincent Mariaule, Sirine Tebassi, Nizar Akermi, Emmanuelle Maguin, Juan Hernandez, Roberto T. Raittz, Moez Rhimi, Francesco Asnicar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |