The cold case of state transition 7 (stt7) mutants of Chlamydomonas reinhardtii, solved by whole‐genome sequencing
Sandrine Bujaldon, Adrien Burlacot, Frédéric Chaux, Francis‐André Wollman · 2026
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Description
Sandrine Bujaldon and colleagues revisit two algal mutants in a 2026 study. Labs have used these mutants for twenty years to study state transitions. That process moves light-harvesting proteins between the two photosystems. One mutant could barely breed. The other leaked the trait it was meant to lack.
Long-read sequencing rebuilt the genomes of the Chlamydomonas strains. The near-sterile strain held big chromosome rearrangements. It also carried extra chromosome copies, larger cells, and faulty reproduction. The team bred and gene-edited two clean replacement mutants. Their warning is plain. Old genetic tools need rechecking before results built on them are trusted.
Catalog record
| CREATOR | Sandrine Bujaldon, Adrien Burlacot, Frédéric Chaux, Francis‐André Wollman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |