Histone Post‐Translational Modifications Regulating Ferroptosis: The Molecular Mechanisms and Disease Associations
Xiaoqian Tang, Haodang Luo, Siqi Gao, Xiaocheng Liu, Qing Sun, Yanhua Zeng · 2026
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Description
Xiaoqian Tang and co-authors published a review paper in 2026 on how chemical tags on histones, the spools that wind DNA, steer a form of cell death called ferroptosis. In this death, iron feeds the rusting of cell fats. Tags on the spools switch genes on or off, including the genes that set a cell's ferroptosis risk.
The review sorts the tags by kind, from methylation to newer marks like lactylation, and by the exact spool site they touch. It then traces how infections, tumors, and chronic diseases ride this control layer to push cells toward or away from the death. Pairing tag-targeting drugs with ferroptosis triggers is floated as a treatment idea.
Catalog record
| CREATOR | Xiaoqian Tang, Haodang Luo, Siqi Gao, Xiaocheng Liu, Qing Sun, Yanhua Zeng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |