Multi-omics-guided metabolic engineering of Limosilactobacillus reuteri for high-level 3-hydroxypropionaldehyde production from glucose
Zuojun Liu, Qiang Yin, Liang Li, Hang Wu, Yong Fang, Fuqiang Cheng, Ting Guo · 2026
Read Multi-omics-guided metabolic engineering of Limosilactobacillus reuteri for high-level 3-hydroxypropionaldehyde production from glucose by Zuojun Liu, Qiang Yin, Liang Li, Hang Wu, Yong Fang, Fuqiang Cheng, Ting Guo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13539820.txt.
Description
Zuojun Liu and six colleagues report a 2026 engineering study of a probiotic bacterium, Limosilactobacillus reuteri, reworked to make a useful antimicrobial compound called 3-HPA from cheap glucose. Three tangled problems held output back: a missing vitamin, an unbalanced cell chemistry, and a brake on sugar use.
Comparing sugars with multi-omics tools, the team found that galactose switches on the needed genes and reroutes carbon flow, even though cells grow poorly on it. Copying that program into a glucose-fed strain, plus feeding four supplements, lifted output many times over the starting level. The authors claim the highest yield yet reported for this bacterial group in flask culture.
Catalog record
| CREATOR | Zuojun Liu, Qiang Yin, Liang Li, Hang Wu, Yong Fang, Fuqiang Cheng, Ting Guo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47757 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |