Modular synthesis of functionalized azetidines through visible-light copper-catalyzed carboamination of 1,3-dienes with azabicyclo[1.1.0]butanes
Yejin Koo, Dongwoo Lee, Jiyong Park, Sungwoo Hong · 2026
Read Modular synthesis of functionalized azetidines through visible-light copper-catalyzed carboamination of 1,3-dienes with azabicyclo[1.1.0]butanes by Yejin Koo, Dongwoo Lee, Jiyong Park, Sungwoo Hong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13539498.txt.
Description
Yejin Koo, Dongwoo Lee, Jiyong Park, and Sungwoo Hong report a light-driven copper method to build azetidines, small four-membered rings prized in drug design. Their 2026 paper uses strained bicyclic starting materials whose stored strain powers ring formation. Past routes to richly decorated azetidines of this kind were limited.
Their four-component reaction joins dienes, amines, and other partners in one step under visible light. A copper and light-harvesting pair work together to form the ring and a new carbon-nitrogen bond. The method tolerates many varied partners and favors one product layout strongly. Tests on complex, biology-linked molecules and a scaled-up run show practical reach. Computer work traces the selectivity to weak attractions that steer the bond formation.
Catalog record
| CREATOR | Yejin Koo, Dongwoo Lee, Jiyong Park, Sungwoo Hong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |