A pH‐Responsive fluorescence lifetime probe reveals GOT1 phase separation in cellular anti‐senescence
Ziyue Chen, Jiaqi Li, Yan Bao, Mengmeng Wang, Haoyan Chen, Mingjiong Zhang, Lina Ding, Shuangshuang Wu, Baoxing Shen · 2026
Read A pH‐Responsive fluorescence lifetime probe reveals GOT1 phase separation in cellular anti‐senescence by Ziyue Chen, Jiaqi Li, Yan Bao, Mengmeng Wang, Haoyan Chen, Mingjiong Zhang, Lina Ding, Shuangshuang Wu, Baoxing Shen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13539394.txt.
Description
As cells age, their inner fluid turns more acidic, and how they sense that shift was unclear. Ziyue Chen and co-authors report a sensing enzyme in this 2026 study. The enzyme, called GOT1, was found at higher levels in aged human lung cells. Under acidic conditions like those in aging cells, the enzyme clumps into droplets, a process called phase separation.
Those droplets pull in a second enzyme and form working clusters that clear harmful oxygen-based chemicals. That cleanup eases the stress that drives cell aging. To watch the process, the team built a glowing probe from the enzyme's own helper molecule. The probe's glow lifetime shifts with acidity, letting them read the enzyme's local conditions. The work links a metabolic enzyme to a defense against cell aging.
Catalog record
| CREATOR | Ziyue Chen, Jiaqi Li, Yan Bao, Mengmeng Wang, Haoyan Chen, Mingjiong Zhang, Lina Ding, Shuangshuang Wu, Baoxing Shen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |