Bile Acid Metabolism as a Unifying Readout for Diet, Microbiome Function, and Gastrointestinal Disease
Jason Dichter · 2026
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Description
Jason Dichter argues a case about bile acids in a 2026 perspective piece. Bile acids were once seen as simple soaps that help digest fat. They are now known to act as signals, and gut microbes reshape them into a wide family of compounds. A 2020 find of microbe-made forms grew the known list from about twenty to over two hundred.
Care has not kept pace with the science. One drug class that targets a bile acid sensor failed in liver trials and left the United States market after safety warnings. Care for bile acid diarrhea still leans on binding drugs from the 1960s and 1970s. Dichter argues the field should unite around the bile acid pool as one shared measure that links diet, microbes, and gut disease.
Catalog record
| CREATOR | Jason Dichter |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |