Efficacy and Safety of Once‐Weekly Semaglutide 2.0 mg as an Add‐On to Dose‐Reduced Insulin Glargine versus Dose‐Titrated Insulin Glargine in People With Type 2 Diabetes and Overweight (SUSTAIN OPTIMIZE)
Helena W Rodbard, Concetta Irace, Jevitha Lobo, Konstantinos Makrilakis, Prachi Priyadarshini, Suvanjaa Sivalingam, Santiago Tofé Povedano, Anuj Bhargava · 2026
Read Efficacy and Safety of Once‐Weekly Semaglutide 2.0 mg as an Add‐On to Dose‐Reduced Insulin Glargine versus Dose‐Titrated Insulin Glargine in People With Type 2 Diabetes and Overweight (SUSTAIN OPTIMIZE) by Helena W Rodbard, Concetta Irace, Jevitha Lobo, Konstantinos Makrilakis, Prachi Priyadarshini, Suvanjaa Sivalingam, Santiago Tofé Povedano, Anuj Bhargava (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13538791.txt.
Description
Helena W Rodbard and colleagues compare adding weekly semaglutide with reduced basal insulin against simply raising insulin in a 2026 randomized study. A total of 573 adults with type 2 diabetes and overweight on modest basal insulin doses were split between the two strategies for forty weeks. Blood sugar control, weight, insulin dose, and treatment satisfaction led the outcomes.
The add-on strategy beat insulin titration on every front, cutting blood sugar averages further, shedding substantially more weight, and slashing daily insulin needs. Satisfaction scores also favored the add-on arm. Severe low blood sugar episodes fell by more than half, though stomach side effects were far more frequent. The authors present the combination as the stronger path for this group.
Catalog record
| CREATOR | Helena W Rodbard, Concetta Irace, Jevitha Lobo, Konstantinos Makrilakis, Prachi Priyadarshini, Suvanjaa Sivalingam, Santiago Tofé Povedano, Anuj Bhargava |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |