Orai1-mediated Ca2+ entry regulates lipolysis and mitochondrial activation in brown adipose thermogenesis
Suji Kim, Phan Anh Nguyen, Kyu-Sang Park, Seung-Kuy Cha, Jun Namkung · 2026
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Description
Kim and co-authors find a calcium gate that drives heat making in brown fat. Brown fat burns energy to keep body heat in the cold. The gate, Orai1, lets calcium into brown fat cells. Mice lacking Orai1 only in brown fat were the test model. Cold exposure triggered calcium entry through a non-standard path.
Without Orai1, fat-splitting enzymes and heat genes fell. Mitochondria took up less calcium and uncoupled less. Mice grew cold-sensitive, stored more fat, and burned less energy. Orai1 helps switch on a cAMP path via adenylyl cyclase 3. The authors name Orai1 as a metabolic drug target.
Catalog record
| CREATOR | Suji Kim, Phan Anh Nguyen, Kyu-Sang Park, Seung-Kuy Cha, Jun Namkung |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |