The effect of Staphylococcus aureus targeting ROS-dependent mitochondrial damage activating NLRP10 in inducing skin and soft tissue infection
Yan Chen, Jieqiong Wei, Shanshan Wang, Mengna Wang, Xiaobo Ying, Chuanling Zhang · 2026
Read The effect of Staphylococcus aureus targeting ROS-dependent mitochondrial damage activating NLRP10 in inducing skin and soft tissue infection by Yan Chen, Jieqiong Wei, Shanshan Wang, Mengna Wang, Xiaobo Ying, Chuanling Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13538666.txt.
Description
Yan Chen and colleagues dissect a regulator protein's role in staph skin infections in a 2026 animal and cell study. Drug-resistant staph causes severe skin and soft tissue infections where cell power units falter and reactive oxygen builds up. Infected mice showed lesions and cell death signals, while skin cells with the regulator lowered or raised revealed opposing effects on power unit damage and inflammatory alarm assembly.
Silencing the regulator worsened power unit stress and cell death yet muted inflammatory alarm output and fluid leakage. Raising it, paired with a power unit antioxidant, eased damage while boosting alarm signaling and a key inflammation switch. The authors cast the regulator as a balancing node between cell survival and inflammatory defense during staph infection.
Catalog record
| CREATOR | Yan Chen, Jieqiong Wei, Shanshan Wang, Mengna Wang, Xiaobo Ying, Chuanling Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47138 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |