Improving Parkinson’s disease diagnosis by non-invasive detection of retinal biomarkers in MPTP monkeys using ERG and pupillometry
Jonathan Munro, Andrée-Anne Lavigne, Shirley Fecteau, Thérèse Di Paolo, Marc Hébert, Martin Parent · 2026
Read Improving Parkinson’s disease diagnosis by non-invasive detection of retinal biomarkers in MPTP monkeys using ERG and pupillometry by Jonathan Munro, Andrée-Anne Lavigne, Shirley Fecteau, Thérèse Di Paolo, Marc Hébert, Martin Parent (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13538655.txt.
Description
Jonathan Munro and colleagues hunted early Parkinson's signs in the eyes of monkeys given a Parkinson's-causing toxin. Published in 2026, the study measured four monkeys before and after MPTP, a toxin that kills dopamine neurons. Parkinson's is now spotted from movement signs, by which time about half the key midbrain signal cells are already gone.
Eye-current tests showed slower daylight-wave timing and smaller wave ripples in both daylight and dim settings after the toxin. Pupils also stayed wider after light, and post-mortem checks found a thinner outer retina layer with fewer signal-making and light-sensing cells. All told, the results point to eye changes that current tests can pick up before movement signs appear. Readers get new early clues for spotting Parkinson's.
Catalog record
| CREATOR | Jonathan Munro, Andrée-Anne Lavigne, Shirley Fecteau, Thérèse Di Paolo, Marc Hébert, Martin Parent |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 89 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |