Linking electric field directionality to treatment outcome in OCD: Insights from patient-specific tDCS modeling
Julie Gosez, Arnaud Germaneau, Karim El Houari, Prasanth Bokam, Michel Rochette, Nicolas Langbour, Rémy Guillevin, Nemat Jaafari, Ghina Harika-Germaneau · 2026
Read Linking electric field directionality to treatment outcome in OCD: Insights from patient-specific tDCS modeling by Julie Gosez, Arnaud Germaneau, Karim El Houari, Prasanth Bokam, Michel Rochette, Nicolas Langbour, Rémy Guillevin, Nemat Jaafari, Ghina Harika-Germaneau (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13538639.txt.
Description
Julie Gosez and colleagues model brain electric fields from scalp stimulation in obsessive-compulsive disorder in a 2026 patient-specific study. Response to the stimulation varies widely in treatment-resistant cases. Forty-two trial patients who received active stimulation had personal head models built from scans, and symptom change was scored on a standard scale with responders clearing a set threshold. Current direction and strength maps were compared voxel by voxel.
Greater inward current in two frontal zones tracked with symptom improvement. Outward current in a lower frontal zone also linked to gains. Field strength alone showed no such links, spotlighting direction as the active ingredient. The authors argue that tailoring stimulation to personal anatomy and current direction could sharpen results in psychiatric care.
Catalog record
| CREATOR | Julie Gosez, Arnaud Germaneau, Karim El Houari, Prasanth Bokam, Michel Rochette, Nicolas Langbour, Rémy Guillevin, Nemat Jaafari, Ghina Harika-Germaneau |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33278 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |