When effective anticancer therapies are, in fact, destabilizing the tumor’s Group Phenotypic Composition
Frédéric Thomas, Antoine M Dujon, Andriy Marusyk, James DeGregori, Alexandre Fontanella, Margaux Bieuville, Mario Campone, Pascal Pujol, Catherine Alix-Panabières, Laurent Lecam, Benjamin Roche, Matthieu Lacroix, Christophe Hirtz, Laurent Poulain, Jean-Pascal Capp, Beata Ujvari, Jordan Meliani, Robe · 2026
Read When effective anticancer therapies are, in fact, destabilizing the tumor’s Group Phenotypic Composition by Frédéric Thomas, Antoine M Dujon, Andriy Marusyk, James DeGregori, Alexandre Fontanella, Margaux Bieuville, Mario Campone, Pascal Pujol, Catherine Alix-Panabières, Laurent Lecam, Benjamin Roche, Matthieu Lacroix, Christophe Hirtz, Laurent Poulain, Jean-Pascal Capp, Beata Ujvari, Jordan Meliani, Robe (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13538637.txt.
Description
Frédéric Thomas and colleagues argued that strong cancer treatments may work by breaking how tumor cells work together. Published in 2026, the essay holds that lasting control often arrives without wiping out every cancer cell. Many therapies succeed, the authors say, by shaking up the tumor's Group Phenotypic Composition, the working layout of linked cell groups.
When that layout collapses, tumors lose their grip and staying power. The authors contrast this view with the kill-the-most-cells model, noting stable disease under light or on-and-off treatment in cases like slow lymph cancers and some prostate and breast cancers. The essay offers one frame for designing treatments aimed at how tumors behave as wholes rather than cell counts alone. Readers get a fresh lens for why modest dosing can hold cancer at bay.
Catalog record
| CREATOR | Frédéric Thomas, Antoine M Dujon, Andriy Marusyk, James DeGregori, Alexandre Fontanella, Margaux Bieuville, Mario Campone, Pascal Pujol, Catherine Alix-Panabières, Laurent Lecam, Benjamin Roche, Matthieu Lacroix, Christophe Hirtz, Laurent Poulain, Jean-Pascal Capp, Beata Ujvari, Jordan Meliani, Robe |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |