The integrated developmental stress response (ISR-DASR) shift reveals a functional transition from cellular to stem cell organismal adaptation
Ximena Ruden, Campbell Coddington, Lynessa Asplund, Awoniyi Awonuga, Douglas Ruden, Steven Korzeniewski, Lijun Zhang, Elizabeth Puscheck, Daniel Rappolee · 2026
Read The integrated developmental stress response (ISR-DASR) shift reveals a functional transition from cellular to stem cell organismal adaptation by Ximena Ruden, Campbell Coddington, Lynessa Asplund, Awoniyi Awonuga, Douglas Ruden, Steven Korzeniewski, Lijun Zhang, Elizabeth Puscheck, Daniel Rappolee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13538602.txt.
Description
Ximena Ruden and colleagues test a two-stage stress response in placental stem cells in a 2026 gene activity study. Stem cells first mount a cell-level survival program, then may shift to a development-linked program favoring the whole organism. Mouse placental stem cells faced strong salt stress. Gene activity was profiled from half an hour through a full day to watch for the same staged shift seen earlier in embryonic stem cells.
Early hours were dominated by building and metabolism genes typical of cell-level adaptation. Later hours swung toward development and differentiation pathways, matching activation of the second program. The authors read the pattern as evidence that the staged shift is a general feature of stressed developmental stem cells. Candidate markers are proposed for fertility care, miscarriage study, and regenerative medicine.
Catalog record
| CREATOR | Ximena Ruden, Campbell Coddington, Lynessa Asplund, Awoniyi Awonuga, Douglas Ruden, Steven Korzeniewski, Lijun Zhang, Elizabeth Puscheck, Daniel Rappolee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63249 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |