Regulatory mechanisms of maternal imprinting at the murine Dlk1-Dio3 domain
Ariella Weinberg-Shukron, Frances L Dearden, Ana Moreno-Barriga, Lok Ting Nick New, Marco Müller, Rebecca C Rancourt, Carol A Edwards, Anne C Ferguson-Smith · 2026
Read Regulatory mechanisms of maternal imprinting at the murine Dlk1-Dio3 domain by Ariella Weinberg-Shukron, Frances L Dearden, Ana Moreno-Barriga, Lok Ting Nick New, Marco Müller, Rebecca C Rancourt, Carol A Edwards, Anne C Ferguson-Smith (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13538571.txt.
Description
Ariella Weinberg-Shukron and co-authors probe how the mother's copy of a large imprinted gene cluster is controlled, in a 2026 mouse study. Imprinting silences genes by parent of origin, and at the Dlk1-Dio3 domain the father's side is governed by a methylated control island. The mother's unmethylated side had no known regulator.
Deleting a small element in the control region changed nothing for maternal genes in embryos, surprisingly, but switched Dlk1 on from both parents. Pairing that deletion with a normally lethal one restored balance and saved the mice. The authors conclude that losing expression harms more than gaining it, and that imprinting control is a layered hierarchy, not methylation alone.
Catalog record
| CREATOR | Ariella Weinberg-Shukron, Frances L Dearden, Ana Moreno-Barriga, Lok Ting Nick New, Marco Müller, Rebecca C Rancourt, Carol A Edwards, Anne C Ferguson-Smith |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 85 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |