Innervated human cardiac muscle model reveals sympathetic drivers of KCNH2-associated arrhythmias
Lennart Valentin Schneider, Michael Gani Setya, Guobin Bao, Daniel Härtter, Aditi Methi, Dennis Krüger, Marie Kristin Schreiber, Ole Jensen, Elisavet Kanari, Kea Aline Schmoll, Narasimha Swamy Telugu, Sadman Sakib, Eun Seo Kim, Aminath Luveysa Fahud, Maham Novin, Aylin Seedorf, Sebastian Diecke, And · 2026
Read Innervated human cardiac muscle model reveals sympathetic drivers of KCNH2-associated arrhythmias by Lennart Valentin Schneider, Michael Gani Setya, Guobin Bao, Daniel Härtter, Aditi Methi, Dennis Krüger, Marie Kristin Schreiber, Ole Jensen, Elisavet Kanari, Kea Aline Schmoll, Narasimha Swamy Telugu, Sadman Sakib, Eun Seo Kim, Aminath Luveysa Fahud, Maham Novin, Aylin Seedorf, Sebastian Diecke, And (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13538559.txt.
Description
Lennart Schneider and co-authors build a nerve linked heart muscle model in a 2026 study. Heart rhythm is steered by nerves, and nerve overdrive can trigger fatal rhythm faults. The team fused nerve cell clusters with lab grown human heart muscle. The model lets them watch nerve and muscle interact directly.
Light pulses on the nerve part changed how the muscle beat, proving live links. A long QT gene fault made nerves overactive and sparked rhythm faults. A nerve calming drug class failed to fix the fault pattern. A drug acting on both nerve and muscle cells worked better.
Catalog record
| CREATOR | Lennart Valentin Schneider, Michael Gani Setya, Guobin Bao, Daniel Härtter, Aditi Methi, Dennis Krüger, Marie Kristin Schreiber, Ole Jensen, Elisavet Kanari, Kea Aline Schmoll, Narasimha Swamy Telugu, Sadman Sakib, Eun Seo Kim, Aminath Luveysa Fahud, Maham Novin, Aylin Seedorf, Sebastian Diecke, And |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 93 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |