Integrated computational and experimental benchmarking of Bacillus phage endolysins reveals the relationship between peptidoglycan-fragment recognition descriptors and antibacterial performance
Roxana Portieles, Xinmin Ma, Jianjian Hu, Yuxiu Xu, Hongli Xu, Nayanci Portal González, Gabriela Santos-Portal, Rabia Durrani, Ramon Santos-Bermúdez, Orlando Borrás-Hidalgo · 2026
Read Integrated computational and experimental benchmarking of Bacillus phage endolysins reveals the relationship between peptidoglycan-fragment recognition descriptors and antibacterial performance by Roxana Portieles, Xinmin Ma, Jianjian Hu, Yuxiu Xu, Hongli Xu, Nayanci Portal González, Gabriela Santos-Portal, Rabia Durrani, Ramon Santos-Bermúdez, Orlando Borrás-Hidalgo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13538476.txt.
Description
Roxana Portieles and co-authors benchmark virus-derived wall-cutting proteins as antibacterials in a 2026 combined computing and lab study. Seven variants from Bacillus-infecting viruses were docked against a tiny wall fragment, simulated over long timescales, scored for binding strength, and tested against two bacterial species. The aim was to learn whether cheap fragment scores predict real killing power well enough to rank candidates.
Most variants recognized the fragment favorably, yet contact styles and stability differed widely. Lab tests crowned one variant as strongest against both species, while two others shone mainly in computing scores. Overall links between fragment scores and killing stayed modest. The authors nominate the lab winner and one runner-up for development, while warning that tiny fragments poorly stand in for whole walls.
Catalog record
| CREATOR | Roxana Portieles, Xinmin Ma, Jianjian Hu, Yuxiu Xu, Hongli Xu, Nayanci Portal González, Gabriela Santos-Portal, Rabia Durrani, Ramon Santos-Bermúdez, Orlando Borrás-Hidalgo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41696 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |