My Love Story With HIFs in the Disc: A Journey to the Humboldt Research Award
Makarand V. Risbud · 2026
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Description
Risbud reviews two decades of work on hypoxia factors in the intervertebral disc and a journey to a Humboldt Award, in a review from twenty twenty-six. The disc is the body's largest tissue without blood vessels. Its center endures low oxygen, acidity, and heavy loading that would kill most cells. Hypoxia-inducible factors emerge as master regulators of survival there.
A surprise finding, HIF one alpha stable without hypoxia, launches the story. HIF one proves essential for disc development and upkeep. HIF two plays an opposing role, driving matrix breakdown and fibrosis. Lactate shuttling between disc and endplate cells adds an epigenetic twist. Collaborations and trainees sustain the program throughout.
Catalog record
| CREATOR | Makarand V. Risbud |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |