Integrated LiP-MS and quantitative proteomics reveal coordinated alterations in protein conformation and expression across tumor and peritumoral regions in hepatocellular carcinoma
Zhen-dong Chen, Min-ying Yang, Xi-ni Wei, Wei Qin, Li Xiao, Yin-yun Qin, Rui-ling Su, Yi-wu Dang, Dan-dan Xiong · 2026
Read Integrated LiP-MS and quantitative proteomics reveal coordinated alterations in protein conformation and expression across tumor and peritumoral regions in hepatocellular carcinoma by Zhen-dong Chen, Min-ying Yang, Xi-ni Wei, Wei Qin, Li Xiao, Yin-yun Qin, Rui-ling Su, Yi-wu Dang, Dan-dan Xiong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13538401.txt.
Description
Chen and colleagues published a 2026 study on hidden protein shape changes in liver cancer. Proteins can misbehave by changing shape even when their amounts stay normal. The team paired two mass-scan methods to read shape and amount together. Samples covered tumor, near-edge, and far-edge tissue from liver cancer patients.
Hundreds of proteins changed shape between tumor and edge tissue zones. Many shape changes came with no change in protein amount at all. Four proteins stood out, rising in both shape signal and amount. Those four also tracked with poorer survival in patient data. Shape reading adds a layer that amount-only studies miss entirely. Hub proteins from the maps offer leads for drug hunting next.
Catalog record
| CREATOR | Zhen-dong Chen, Min-ying Yang, Xi-ni Wei, Wei Qin, Li Xiao, Yin-yun Qin, Rui-ling Su, Yi-wu Dang, Dan-dan Xiong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |