Glucose starvation induces fumarate hydratase succinylation and inhibits ferroptosis to maintain colon cancer cell proliferation
L. T. Sun, X. H. Qin, Y. D. Zheng, Z. Y. Zhang, Q. Wang · 2026
Read Glucose starvation induces fumarate hydratase succinylation and inhibits ferroptosis to maintain colon cancer cell proliferation by L. T. Sun, X. H. Qin, Y. D. Zheng, Z. Y. Zhang, Q. Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13538377.txt.
Description
L. T. Sun and colleagues uncover how colon cancer cells survive sugar shortage in a 2026 cell study. Fast growth and poor blood supply leave tumor centers starved of glucose, yet cells keep dividing. Focus falls on fumarate hydratase, an energy cycle enzyme that runs low in this cancer and normally restrains growth. Starvation tests, gene activity checks, and protein tracking traced a chemical tagging process on the enzyme.
Starved cells tagged the enzyme for destruction through a cleanup route, letting its raw materials pile up. Piled fumarate stabilized a protective protein that raised two guards against iron-driven cell death, letting cancer cells keep growing. The authors frame the enzyme and its tagging as fresh drug targets for blocking starvation adaptation in colon cancer.
Catalog record
| CREATOR | L. T. Sun, X. H. Qin, Y. D. Zheng, Z. Y. Zhang, Q. Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71462 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |