Inhibition of ERK5 activity ameliorates osteoarthritis by suppressing NLRP3 inflammasome-mediated chondrocyte pyroptosis
Baolin Zhang, Peihang Fang, Jiahui Long, Deying Su, Hengyu Liu, Ricong Weng, Gengjia Chen, Yingtong Chen, GuanHong Chen, Zhiheng Liao, Taifeng Zhou, Shuqing Chen, Peiqiang Su, Caixia Xu · 2026
Read Inhibition of ERK5 activity ameliorates osteoarthritis by suppressing NLRP3 inflammasome-mediated chondrocyte pyroptosis by Baolin Zhang, Peihang Fang, Jiahui Long, Deying Su, Hengyu Liu, Ricong Weng, Gengjia Chen, Yingtong Chen, GuanHong Chen, Zhiheng Liao, Taifeng Zhou, Shuqing Chen, Peiqiang Su, Caixia Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13538362.txt.
Description
Baolin Zhang and a large co-author team pin down, in 2026 work, a driver of joint wear in mice and human tissue. The wear disease brings lasting pain and lost function, yet its core paths are still not fully mapped. Their data show one enzyme running far hotter in worn joints from people and old mice.
When the gene for that enzyme was cut in mouse joint cells, wear after injury or age slowed. When it was forced on, wear sped up. The enzyme lights a danger hub inside the cells, which kills them in a fiery mode and feeds the wear. A plant compound that calms the enzyme eased wear in mice too. The team names the enzyme a strong drug target.
Catalog record
| CREATOR | Baolin Zhang, Peihang Fang, Jiahui Long, Deying Su, Hengyu Liu, Ricong Weng, Gengjia Chen, Yingtong Chen, GuanHong Chen, Zhiheng Liao, Taifeng Zhou, Shuqing Chen, Peiqiang Su, Caixia Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |