A dimeric mRNA vaccine based on key-mutant and KP.3 RBDs induces broad-spectrum immunity and protects mice against JN.1 and XDV challenges
Jiali Xu, Rui Peng, Longhai Yuan, Huan Zhang, Cong Tang, Yanan Zhou, Hao Yang, Yun Yang, Qing Huang, Junbin Wang, Hongyu Chen, Wenqi Quan, Baisheng Li, Qiangming Sun, Shuaiyao Lu · 2026
Read A dimeric mRNA vaccine based on key-mutant and KP.3 RBDs induces broad-spectrum immunity and protects mice against JN.1 and XDV challenges by Jiali Xu, Rui Peng, Longhai Yuan, Huan Zhang, Cong Tang, Yanan Zhou, Hao Yang, Yun Yang, Qing Huang, Junbin Wang, Hongyu Chen, Wenqi Quan, Baisheng Li, Qiangming Sun, Shuaiyao Lu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13538340.txt.
Description
Jiali Xu and co-authors test a two-part mRNA vaccine against COVID variants in a 2026 mouse study. New Omicron offshoots keep eroding vaccine cover, so broader shots are in demand. Their shot joins two binding domains from split strains in one strand.
Two doses in mice raised strong neutralizing antibodies that crossed many variants, from early Omicron lines to a distant one. Immune cell records showed deep reshaping of both B and T cell pools. In two mouse types, the shot cut lung virus loads hard after challenge with two strains. The design shows how pairing split domains can widen cover.
Catalog record
| CREATOR | Jiali Xu, Rui Peng, Longhai Yuan, Huan Zhang, Cong Tang, Yanan Zhou, Hao Yang, Yun Yang, Qing Huang, Junbin Wang, Hongyu Chen, Wenqi Quan, Baisheng Li, Qiangming Sun, Shuaiyao Lu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |