Integration of network pharmacology, molecular docking, and molecular dynamics simulation to elucidate the mechanism of Psychotria rubra in depression treatment
Li Yin, Chengshu Lu, Ju Ye, Yewen Zhang, Shirui Mo, Huakun Wang · 2026
Read Integration of network pharmacology, molecular docking, and molecular dynamics simulation to elucidate the mechanism of Psychotria rubra in depression treatment by Li Yin, Chengshu Lu, Ju Ye, Yewen Zhang, Shirui Mo, Huakun Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13538335.txt.
Description
Psychotria rubra is a plant used in southern China, and early reports link it to relief from low mood. Li Yin and co-authors set out in 2026 to learn how the plant might act against depression. They combined gene data work, computer models of molecule binding, and tests in stressed mice, rather than relying on one method alone.
The team compared gene patterns in blood from people with depression and healthy peers, then screened key genes with machine learning. Computer runs tested how plant compounds fit those gene targets. In mice, several plant compounds were given after three weeks of stress, and mood tests, brain signals, and cell damage markers were tracked.
Catalog record
| CREATOR | Li Yin, Chengshu Lu, Ju Ye, Yewen Zhang, Shirui Mo, Huakun Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |