Integrated bulk and single-cell RNA sequencing reveals a prognostic neuro-mimicry signature in papillary thyroid carcinoma
Xinyu Liu, Chengjin Mei, Jifeng Tan, Yanlan Liu, Yuyao Liu, Zhigang Zhou, Jianfu Zhao · 2026
Read Integrated bulk and single-cell RNA sequencing reveals a prognostic neuro-mimicry signature in papillary thyroid carcinoma by Xinyu Liu, Chengjin Mei, Jifeng Tan, Yanlan Liu, Yuyao Liu, Zhigang Zhou, Jianfu Zhao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13538332.txt.
Description
Xinyu Liu and co-authors build a neuron-like gene signature for papillary thyroid cancer in a 2026 study mixing bulk and single-cell gene data. Cancer cells can borrow nerve-like traits to advance, yet relevant channel genes in this cancer were unclear. Bulk data from 521 patients supplied an eight-gene model for spread to neck lymph nodes. Single-cell data from seven tumors then traced which cells actually carry the signals.
The eight-gene model predicted node spread with fair accuracy. Single-cell checks showed one gene, GABRB2, concentrated in malignant thyroid cells at rates far above immune cells, supporting tumor-born nerve mimicry rather than background noise. High-risk patients showed a more suppressed immune pattern with shifted cell entry. The authors suggest channel targeting as a possible future lever, pending lab validation.
Catalog record
| CREATOR | Xinyu Liu, Chengjin Mei, Jifeng Tan, Yanlan Liu, Yuyao Liu, Zhigang Zhou, Jianfu Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32401 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |