A late-stage multi-dimensional intervention rescues lethal viral pneumonia in an aged hamster model
Ming Zhou, Xuan Liu, Jinxin Miao, Yanzhen Lin, Haiqing Xiao, Kun Wu, Longmei Zhang, Xinglin Li, Xinyi Yang, Lin Chen, Jian Ma, Wei Wang, Nan Xu, Jiang Li, Huachen Zhu, Yi Guan, Ningshao Xia, Tong Cheng, Lunzhi Yuan · 2026
Read A late-stage multi-dimensional intervention rescues lethal viral pneumonia in an aged hamster model by Ming Zhou, Xuan Liu, Jinxin Miao, Yanzhen Lin, Haiqing Xiao, Kun Wu, Longmei Zhang, Xinglin Li, Xinyi Yang, Lin Chen, Jian Ma, Wei Wang, Nan Xu, Jiang Li, Huachen Zhu, Yi Guan, Ningshao Xia, Tong Cheng, Lunzhi Yuan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13538324.txt.
Description
Ming Zhou and colleagues report a two thousand twenty-six study rescuing aged hamsters from lethal viral pneumonia with a late multi-part intervention. Ageing itself drives deadly outcomes in respiratory virus infections worldwide. Old hamsters infected with the coronavirus showed distinct lung damage patterns.
Gene profiling revealed widespread cell death, weak antiviral responses, and inflammation-driven clotting in aged lungs. Adult animals pushed toward the same aged pattern when infected with the virus. A combined late intervention targeting several of these dimensions reversed the lethal course. Multi-angle treatment, started late, may matter most for elderly patients.
Catalog record
| CREATOR | Ming Zhou, Xuan Liu, Jinxin Miao, Yanzhen Lin, Haiqing Xiao, Kun Wu, Longmei Zhang, Xinglin Li, Xinyi Yang, Lin Chen, Jian Ma, Wei Wang, Nan Xu, Jiang Li, Huachen Zhu, Yi Guan, Ningshao Xia, Tong Cheng, Lunzhi Yuan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |