A design of experiments study of nasal spray deposition in the alberta idealized nasal inlet
Mathilde Sophie Felding, Charlotte Cubbin, Claus Moser, Fatemeh Ajalloueian, Line Hagner Nielsen · 2026
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Description
Mathilde Felding and four co-authors map what steers where a nasal spray lands inside a model nose, in a 2026 journal article. Sprays up the nose act fast and dodge whole body side effects. The prize zone is the turbinate wall, where uptake is best. Rules for testing where the dose lands are still missing.
The team used a standard lab model of the nose inlet and sprayed a sold brand into it. A planned test grid varied air flow, spray angle, and heat one by one and in pairs. All three shaped the land pattern. Angle and heat mattered most, and pairs of factors pulled together in ways single tests would miss. The authors urge labs to run tests at body like heat.
Catalog record
| CREATOR | Mathilde Sophie Felding, Charlotte Cubbin, Claus Moser, Fatemeh Ajalloueian, Line Hagner Nielsen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |