Musashi‐1 Drives Radioresistance and Stemness in Head and Neck Squamous Cell Carcinoma via a Radioresistant FaDu Model
Na‐Eun Kang, Chan‐Woong Jung, Yun‐Ju Kim, Sung‐Gil Chi, Jeong‐Yub Kim, Myung‐Jin Park · 2026
Read Musashi‐1 Drives Radioresistance and Stemness in Head and Neck Squamous Cell Carcinoma via a Radioresistant FaDu Model by Na‐Eun Kang, Chan‐Woong Jung, Yun‐Ju Kim, Sung‐Gil Chi, Jeong‐Yub Kim, Myung‐Jin Park (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13537902.txt.
Description
Na-Eun Kang and co-authors traced, in a 2026 study, how an RNA-binding protein helps head and neck tumors survive radiation. Such cancers are often treated with radiotherapy, yet resistant cells with stem-like traits regrow. The team bred a resistant line of tumor cells by dosing them again and again with radiation.
The survivors grew slower but showed far stronger stem cell behavior in sphere and colony tests. Among stem markers, Musashi-1 rose the most. Silencing it stripped the resistant cells of both stemness and radiation toughness, while forcing it into ordinary cells granted both. Gene profiles pointed to a hyperactive MAPK pathway, with the JNK branch driving the protein's rise. Blocking that branch, the authors suggest, could reopen resistant tumors to radiation.
Catalog record
| CREATOR | Na‐Eun Kang, Chan‐Woong Jung, Yun‐Ju Kim, Sung‐Gil Chi, Jeong‐Yub Kim, Myung‐Jin Park |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |