Integrative proteomics reveals MSH6 to modulate PARP inhibitor sensitivity in BRCA1/2-proficient ovarian cancer
Ou Deng, Thales Da Costa Nepomuceno, Bin Fang, Eric A. Welsh, Victoria Izumi, Rachael H. Martin, Erin M. George, John M. Koomen, Alvaro N. Monteiro, Uwe Rix, Giovanni Nassa, Giovanni Nassa, Giovanni Nassa, Giovanni Nassa · 2026
Read Integrative proteomics reveals MSH6 to modulate PARP inhibitor sensitivity in BRCA1/2-proficient ovarian cancer by Ou Deng, Thales Da Costa Nepomuceno, Bin Fang, Eric A. Welsh, Victoria Izumi, Rachael H. Martin, Erin M. George, John M. Koomen, Alvaro N. Monteiro, Uwe Rix, Giovanni Nassa, Giovanni Nassa, Giovanni Nassa, Giovanni Nassa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13537606.txt.
Description
Some ovarian cancers answer PARP-blocking drugs even without the classic BRCA faults, and a DNA repair protein may explain why. Ou Deng and co-authors compared drug-sensitive and drug-resistant cancer cell lines with normal BRCA genes. Chemical fishing with the drug pulled out different protein teams. One protein, MSH6, clustered more in the sensitive cells' drug complex. Tagging studies showed distinct signaling patterns between the groups as well.
Removing MSH6 made sensitive cells resist the drug. A growth pathway also answered the drug in opposite directions across the groups. The findings nominate MSH6 as a marker for who may benefit beyond the BRCA rule. Protein-team reading, the authors argue, beats gene lists alone for such calls.
Catalog record
| CREATOR | Ou Deng, Thales Da Costa Nepomuceno, Bin Fang, Eric A. Welsh, Victoria Izumi, Rachael H. Martin, Erin M. George, John M. Koomen, Alvaro N. Monteiro, Uwe Rix, Giovanni Nassa, Giovanni Nassa, Giovanni Nassa, Giovanni Nassa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 106 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |