Characterizing social motivation deficits in treatment‐resistant schizophrenia: Evidence from social incentive performance
Simon SY Lui, Jasmine WS Chan, Jason LF Chan, Kimi HY Lam, Lok‐Yin Choi, Raisie WK Wong, Perry BM Leung, Na Zhan, Jason WY Wong, Mindi WY Chiu, Jenny PH Lam, Raymond CK Chan · 2026
Read Characterizing social motivation deficits in treatment‐resistant schizophrenia: Evidence from social incentive performance by Simon SY Lui, Jasmine WS Chan, Jason LF Chan, Kimi HY Lam, Lok‐Yin Choi, Raisie WK Wong, Perry BM Leung, Na Zhan, Jason WY Wong, Mindi WY Chiu, Jenny PH Lam, Raymond CK Chan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13537369.txt.
Description
Simon SY Lui and colleagues probe social motivation in treatment-resistant schizophrenia in a 2026 task study. Social motivation means seeking social reward and avoiding social punishment, and weakness here ties to negative symptoms. Sixty patients with resistant illness, sixty patients in remission, and sixty controls played a timed target game for happy, neutral, or unhappy face outcomes. Pleasure before and after outcomes was also rated.
Resistant patients showed flatter pleasure responses, with expected and received pleasure swayed less by social reward or punishment than in controls. Negative symptoms predicted game accuracy among patients, linking symptom load to social drive processing. The authors propose social motivation weakness as a treatment target for negative symptoms and poor social functioning in resistant illness.
Catalog record
| CREATOR | Simon SY Lui, Jasmine WS Chan, Jason LF Chan, Kimi HY Lam, Lok‐Yin Choi, Raisie WK Wong, Perry BM Leung, Na Zhan, Jason WY Wong, Mindi WY Chiu, Jenny PH Lam, Raymond CK Chan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62272 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |